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Design of a novel Thiophene Inhibitor of 15-Lipoxygenase-1 with both Anti-inflammatory and Neuroprotective Properties

The enzyme 15-lipoxygenase-1 (15-LOX-1) plays a dual role in diseases with an inflammatory component. On one hand 15-LOX-1 plays a role in pro-inflammatory gene expression and on the other hand it has been shown to be involved in central nervous system (CNS) disorders by its ability to mediate oxida...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Eleftheriadis, Nikolaos, Poelman, Hessel, Leus, Niek G. J., Honrath, Birgit, Neochoritis, Constantinos G., Dolga, Amalia, Dömling, Alexander, Dekker, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010146/
https://ncbi.nlm.nih.gov/pubmed/27477687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.07.010
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