Targeting Histone Demethylases: A New Avenue for the Fight against Cancer

Por Rotili, Dante, Mai, Antonello
Publicado em 2011

Histone deacetylase inhibitors and hemoglobin F induction in β-thalassemia

Por Migliaccio, Anna Rita, Rotili, Dante, Nebbioso, Angela, Atweh, George, Mai, Antonello
Publicado em 2008

c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition

Por Palumbo, Camilla, De Luca, Anastasia, Rosato, Nicola, Forgione, Mariantonietta, Rotili, Dante, Caccuri, Anna Maria
Publicado no J Transl Med (2016)

Towards the development of activity-based probes for detection of Lysine-Specific Demethylase-1 activity

Por Ourailidou, Maria E., Lenoci, Alessia, Zwergel, Clemens, Rotili, Dante, Mai, Antonello, Dekker, Frank J.
Publicado no Bioorg Med Chem (2016)

Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer’s disease

Por Scuderi, Caterina, Stecca, Claudia, Bronzuoli, Maria R., Rotili, Dante, Valente, Sergio, Mai, Antonello, Steardo, Luca
Publicado em 2014

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells

Por Chano, Tokuhiro, Avnet, Sofia, Kusuzaki, Katsuyuki, Bonuccelli, Gloria, Sonveaux, Pierre, Rotili, Dante, Mai, Antonello, Baldini, Nicola
Publicado no Am J Cancer Res (2016)

Enzyme kinetics and inhibition of histone acetyltransferase KAT8

Por Wapenaar, Hannah, van der Wouden, Petra E., Groves, Matthew R., Rotili, Dante, Mai, Antonello, Dekker, Frank J.
Publicado no Eur J Med Chem (2015)

"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for...

Por Savarino, Andrea, Mai, Antonello, Norelli, Sandro, El Daker, Sary, Valente, Sergio, Rotili, Dante, Altucci, Lucia, Palamara, Anna Teresa, Garaci, Enrico
Publicado em 2009

Targeting Lysine Deacetylases (KDACs) in Parasites

Por Wang, Qi, Rosa, Bruce A., Nare, Bakela, Powell, Kerrie, Valente, Sergio, Rotili, Dante, Mai, Antonello, Marshall, Garland R., Mitreva, Makedonka
Publicado no PLoS Negl Trop Dis (2015)

Sirtuin functions and modulation: from chemistry to the clinic

Por Carafa, Vincenzo, Rotili, Dante, Forgione, Mariantonietta, Cuomo, Francesca, Serretiello, Enrica, Hailu, Gebremedhin Solomon, Jarho, Elina, Lahtela-Kakkonen, Maija, Mai, Antonello, Altucci, Lucia
Publicado no Clin Epigenetics (2016)

An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases

Por Upadhyay, Anup K., Rotili, Dante, Han, Ji Woong, Hu, Ruogu, Chang, Yanqi, Labella, Donatella, Zhang, Xing, Yoon, Young-sup, Mai, Antonello, Cheng, Xiaodong
Publicado em 2011

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features

Por Speranzini, Valentina, Rotili, Dante, Ciossani, Giuseppe, Pilotto, Simona, Marrocco, Biagina, Forgione, Mariantonietta, Lucidi, Alessia, Forneris, Federico, Mehdipour, Parinaz, Velankar, Sameer, Mai, Antonello, Mattevi, Andrea
Publicado no Sci Adv (2016)

A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts

Por De Luca, Anastasia, Rotili, Dante, Carpanese, Debora, Lenoci, Alessia, Calderan, Laura, Scimeca, Manuel, Mai, Antonello, Bonanno, Elena, Rosato, Antonio, Geroni, Cristina, Quintieri, Luigi, Caccuri, Anna Maria
Publicado no Oncotarget (2015)

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes

Por Nebbioso, Angela, Manzo, Fabio, Miceli, Marco, Conte, Mariarosaria, Manente, Lucrezia, Baldi, Alfonso, De Luca, Antonio, Rotili, Dante, Valente, Sergio, Mai, Antonello, Usiello, Alessandro, Gronemeyer, Hinrich, Altucci, Lucia
Publicado em 2009

Evaluation of Histone Deacetylases as Drug Targets in Huntington’s Disease models: Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients...

Por Quinti, Luisa, Chopra, Vanita, Rotili, Dante, Valente, Sergio, Amore, Allison, Franci, Gianluigi, Meade, Sarah, Valenza, Marta, Altucci, Lucia, Maxwell, Michele M., Cattaneo, Elena, Hersch, Steven, Mai, Antonello, Kazantsev, Aleksey
Publicado em 2010

IκB Kinase ε Targets Interferon Regulatory Factor 1 in Activated T Lymphocytes

Por Sgarbanti, Marco, Marsili, Giulia, Remoli, Anna Lisa, Stellacci, Emilia, Mai, Antonello, Rotili, Dante, Perrotti, Edvige, Acchioni, Chiara, Orsatti, Roberto, Iraci, Nunzio, Ferrari, Mathieu, Borsetti, Alessandra, Hiscott, John, Battistini, Angela
Publicado em 2014

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

Por van den Bosch, Thea, Boichenko, Alexander, Leus, Niek G. J., Eleni Ourailidou, Maria, Wapenaar, Hannah, Rotili, Dante, Mai, Antonello, Imhof, Axel, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.
Publicado no Biochem Pharmacol (2015)

A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases

Por Rotili, Dante, Altun, Mikael, Kawamura, Akane, Wolf, Alexander, Fischer, Roman, Leung, Ivanhoe K. H., Mackeen, Mukram M., Tian, Ya-min, Ratcliffe, Peter J., Mai, Antonello, Kessler, Benedikt M., Schofield, Christopher J.
Publicado no Chem Biol (2011)

PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage

Por Martire, Sara, Fuso, Andrea, Rotili, Dante, Tempera, Italo, Giordano, Cesare, De Zottis, Ivana, Muzi, Alessia, Vernole, Patrizia, Graziani, Grazia, Lococo, Emanuela, Faraldi, Martina, Maras, Bruno, Scarpa, Sigfrido, Mosca, Luciana, d'Erme, Maria
Publicado em 2013

The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis

Por Luca, Anastasia De, Carpanese, Debora, Rapanotti, Maria Cristina, Viguria, Tara Mayte Suarez, Forgione, Maria Antonietta, Rotili, Dante, Fulci, Chiara, Iorio, Egidio, Quintieri, Luigi, Chimenti, Sergio, Bianchi, Luca, Rosato, Antonio, Caccuri, Anna Maria
Publicado no Oncotarget (2017)