"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

Latently infected, resting memory CD4(+ )T cells and macrophages represent a major obstacle to the eradication of HIV-1. For this purpose, "shock and kill" strategies have been proposed (activation of HIV-1 followed by stimuli leading to cell death). Histone deacetylase inhibitors (HDACIs)...

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Detalhes bibliográficos
Main Authors: Savarino, Andrea, Mai, Antonello, Norelli, Sandro, El Daker, Sary, Valente, Sergio, Rotili, Dante, Altucci, Lucia, Palamara, Anna Teresa, Garaci, Enrico
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697151/
https://ncbi.nlm.nih.gov/pubmed/19486542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-52
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