The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma

Melphalan (L-PAM) has been an integral part of multiple myeloma (MM) treatment as a conditioning regimen before stem cell transplant (SCT). After initial response, most treated patients experience relapse with an aggressive phenotype. Increased glutathione (GSH) in MM may mediate resistance to L-PAM...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Tagde, A, Singh, H, Kang, M H, Reynolds, C P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219442/
https://ncbi.nlm.nih.gov/pubmed/25036800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.45
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