Evaluation of Histone Deacetylases as Drug Targets in Huntington’s Disease models: Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model.

The family of histone deacetylases (HDACs) has recently emerged as important drug targets for treatment of slow progressive neurodegenerative disorders, including Huntington’s disease (HD). Broad pharmaceutical inhibition of HDACs has shown neuroprotective effects in various HD models. Here we exami...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Quinti, Luisa, Chopra, Vanita, Rotili, Dante, Valente, Sergio, Amore, Allison, Franci, Gianluigi, Meade, Sarah, Valenza, Marta, Altucci, Lucia, Maxwell, Michele M., Cattaneo, Elena, Hersch, Steven, Mai, Antonello, Kazantsev, Aleksey
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2010
Θέματα:
Huntington Disease
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943247/
https://ncbi.nlm.nih.gov/pubmed/20877454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.RRN1172
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