Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes

Histone deacetylase (HDAC) inhibitors are promising new epi-drugs, but the presence of both class I and class II enzymes in HDAC complexes precludes a detailed elucidation of the individual HDAC functions. By using the class II-specific HDAC inhibitor MC1568, we separated class I- and class II-depen...

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Hlavní autoři: Nebbioso, Angela, Manzo, Fabio, Miceli, Marco, Conte, Mariarosaria, Manente, Lucrezia, Baldi, Alfonso, De Luca, Antonio, Rotili, Dante, Valente, Sergio, Mai, Antonello, Usiello, Alessandro, Gronemeyer, Hinrich, Altucci, Lucia
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
Témata:
Scientific Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693879/
https://ncbi.nlm.nih.gov/pubmed/19498465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.88
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