c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition

BACKGROUND: Nitrobenzoxadiazole derivatives (NBDs), including NBDHEX and the recently developed MC3181, are promising anticancer agents able to target glutathione transferase and inhibit both its catalytic activity and ability to sequester TNF-receptor associated factor 2 (TRAF2) and c-Jun N-termina...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Transl Med
Egile Nagusiak: Palumbo, Camilla, De Luca, Anastasia, Rosato, Nicola, Forgione, Mariantonietta, Rotili, Dante, Caccuri, Anna Maria
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2016
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743117/
https://ncbi.nlm.nih.gov/pubmed/26847645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0796-x
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