Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation

Por Tian, Ya-Min, Mole, David R., Ratcliffe, Peter J., Gleadle, Jonathan M.
Publicado em 2006

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer

Por Salama, Rafik, Masson, Norma, Simpson, Peter, Sciesielski, Lina Katrin, Sun, Min, Tian, Ya-Min, Ratcliffe, Peter John, Mole, David Robert
Publicado no PLoS One (2015)

Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis

Por Willam, Carsten, Masson, Norma, Tian, Ya-Min, Mahmood, S. Aleema, Wilson, Michael I., Bicknell, Roy, Eckardt, Kai-Uwe, Maxwell, Patrick H., Ratcliffe, Peter J., Pugh, Christopher W.
Publicado em 2002

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

Por Masson, Norma, Singleton, Rachelle S, Sekirnik, Rok, Trudgian, David C, Ambrose, Lucy J, Miranda, Melroy X, Tian, Ya-Min, Kessler, Benedikt M, Schofield, Christopher J, Ratcliffe, Peter J
Publicado em 2012

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

Por Tian, Ya-Min, Yeoh, Kar Kheng, Lee, Myung Kyu, Eriksson, Tuula, Kessler, Benedikt M., Kramer, Holger B., Edelmann, Mariola J., Willam, Carsten, Pugh, Christopher W., Schofield, Christopher J., Ratcliffe, Peter J.
Publicado em 2011

A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases

Por Rotili, Dante, Altun, Mikael, Kawamura, Akane, Wolf, Alexander, Fischer, Roman, Leung, Ivanhoe K. H., Mackeen, Mukram M., Tian, Ya-min, Ratcliffe, Peter J., Mai, Antonello, Kessler, Benedikt M., Schofield, Christopher J.
Publicado no Chem Biol (2011)

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

Por Camps, Carme, Saini, Harpreet K, Mole, David R, Choudhry, Hani, Reczko, Martin, Guerra-Assunção, José Afonso, Tian, Ya-Min, Buffa, Francesca M, Harris, Adrian L, Hatzigeorgiou, Artemis G, Enright, Anton J, Ragoussis, Jiannis
Publicado em 2014

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Por Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Tian, Ya-Min, Abboud, Martine I., Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P., Pugh, Christopher W., Ratcliffe, Peter J., Claridge, Timothy D. W., Schofield, Christopher J.
Publicado no Nat Commun (2016)

Dual-Action Inhibitors of HIF Prolyl Hydroxylases That Induce Binding of a Second Iron Ion

Por Yeoh, Kar Kheng, Chan, Mun Chiang, Thalhammer, Armin, Demetriades, Marina, Chowdhury, Rasheduzzaman, Tian, Ya-Min, Stolze, Ineke, McNeill, Luke A., Lee, Myung Kyu, Woon, Esther C. Y., Mackeen, Mukram M., Kawamura, Akane, Ratcliffe, Peter J., Mecinović, Jasmin, Schofield, Christopher J.
Publicado no Org Biomol Chem (2012)

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

Por Chan, Mun Chiang, Atasoylu, Onur, Hodson, Emma, Tumber, Anthony, Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Gómez-Pérez, Verónica, Demetriades, Marina, Rydzik, Anna M., Holt-Martyn, James, Tian, Ya-Min, Bishop, Tammie, Claridge, Timothy D. W., Kawamura, Akane, Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado no PLoS One (2015)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Por Chowdhury, Rasheduzzaman, Yeoh, Kar Kheng, Tian, Ya-Min, Hillringhaus, Lars, Bagg, Eleanor A, Rose, Nathan R, Leung, Ivanhoe K H, Li, Xuan S, Woon, Esther C Y, Yang, Ming, McDonough, Michael A, King, Oliver N, Clifton, Ian J, Klose, Robert J, Claridge, Timothy D W, Ratcliffe, Peter J, Schofield, Christopher J, Kawamura, Akane
Publicado em 2011

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Por Mazzone, Massimiliano, Dettori, Daniela, de Oliveira, Rodrigo Leite, Loges, Sonja, Schmidt, Thomas, Jonckx, Bart, Tian, Ya-Min, Lanahan, Anthony A., Pollard, Patrick, de Almodovar, Carmen Ruiz, De Smet, Frederik, Vinckier, Stefan, Aragonés, Julián, Debackere, Koen, Luttun, Aernout, Wyns, Sabine, Jordan, Benedicte, Pisacane, Alberto, Gallez, Bernard, Lampugnani, Maria Grazia, Dejana, Elisabetta, Simons, Michael, Ratcliffe, Peter, Maxwell, Patrick, Carmeliet, Peter
Publicado em 2009