The relevance of K(i) calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor

Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and disease. A disturbance of these modifications can result in disease states, such as cancer or inflammatory diseases. Inhibitors of HATs (HATi)...

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Udgivet i:Eur J Med Chem
Main Authors: Wapenaar, Hannah, van den Bosch, Thea, Leus, Niek G. J., van der Wouden, Petra E., Eleftheriadis, Nikolaos, Hermans, Jos, Hailu, Gebremedhin Solomon, Rotili, Dante, Mai, Antonello, Dömling, Alexander, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720340/
https://ncbi.nlm.nih.gov/pubmed/28527406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.05.015
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