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Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor

The melanocortin receptors are involved in many physiological functions, including pigmentation, sexual function, feeding behavior, and energy homeostasis, making them potential targets to treat obesity, sexual dysfunction, etc. Understanding the basis of the ligand-receptor interactions is crucial...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Grieco, Paolo, Brancaccio, Diego, Novellino, Ettore, Hruby, Victor J., Carotenuto, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102844/
https://ncbi.nlm.nih.gov/pubmed/21652123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.05.038
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