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Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

Many cancers have the tumor suppressor p53 inactivated by mutation, making reactivation of mutant p53 with small molecules a promising strategy for the development of novel anticancer therapeutics. The oncogenic p53 mutation Y220C, which accounts for approximately 100,000 cancer cases per year, crea...

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Detaylı Bibliyografya
Yayımlandı:Eur J Med Chem
Asıl Yazarlar: Baud, Matthias G.J., Bauer, Matthias R., Verduci, Lorena, Dingler, Felix A., Patel, Ketan J., Horil Roy, Deeptee, Joerger, Andreas C., Fersht, Alan R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Editions Scientifiques Elsevier 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986712/
https://ncbi.nlm.nih.gov/pubmed/29702446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.04.035
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