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An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein

The p53 tumor suppressor protein performs a critical role in stimulating apoptosis and cell cycle arrest in response to oncogenic stress. The function of p53 can be compromised by mutation, leading to increased risk of cancer; approximately 50% of cancers are associated with mutations in the p53 gen...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Protein Eng Des Sel
Egile Nagusiak: Bromley, Dennis, Bauer, Matthias R., Fersht, Alan R., Daggett, Valerie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001139/
https://ncbi.nlm.nih.gov/pubmed/27503952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw035
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