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Tumorigenic p53 mutants undergo common structural disruptions including conversion to α‐sheet structure

The p53 protein is a commonly studied cancer target because of its role in tumor suppression. Unfortunately, it is susceptible to mutation‐associated loss of function; approximately 50% of cancers are associated with mutations to p53, the majority of which are located in the central DNA‐binding doma...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Protein Sci
Hauptverfasser: Bromley, Dennis, Daggett, Valerie
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454552/
https://ncbi.nlm.nih.gov/pubmed/32715544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3921
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