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Tumorigenic p53 mutants undergo common structural disruptions including conversion to α‐sheet structure
The p53 protein is a commonly studied cancer target because of its role in tumor suppression. Unfortunately, it is susceptible to mutation‐associated loss of function; approximately 50% of cancers are associated with mutations to p53, the majority of which are located in the central DNA‐binding doma...
Tallennettuna:
| Julkaisussa: | Protein Sci |
|---|---|
| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
John Wiley & Sons, Inc.
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7454552/ https://ncbi.nlm.nih.gov/pubmed/32715544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3921 |
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