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Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA

The tumour suppressor p53 is a transcription factor that binds DNA in the vicinity of the genes it controls. The affinity of p53 for specific binding sites relative to other DNA sequences is an inherent driving force for specificity, all other things being equal. We measured the binding affinities o...

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Библиографические подробности
Главные авторы: Veprintsev, Dmitry B., Fersht, Alan R.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275157/
https://ncbi.nlm.nih.gov/pubmed/18234719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1040
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