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Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA

The tumour suppressor p53 is a transcription factor that binds DNA in the vicinity of the genes it controls. The affinity of p53 for specific binding sites relative to other DNA sequences is an inherent driving force for specificity, all other things being equal. We measured the binding affinities o...

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Bibliografiske detaljer
Main Authors: Veprintsev, Dmitry B., Fersht, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275157/
https://ncbi.nlm.nih.gov/pubmed/18234719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1040
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