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Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor

S100B protein is elevated in the brains of patients with early stages of Alzheimer's disease and Down's syndrome. S100A4 is correlated with the development of metastasis. Both proteins bind to p53 tumor suppressor. We found that both S100B and S100A4 bind to the tetramerization domain of p...

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Bibliographic Details
Main Authors: Fernandez-Fernandez, Maria Rosario, Veprintsev, Dmitry B., Fersht, Alan R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC555715/
https://ncbi.nlm.nih.gov/pubmed/15781852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501459102
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