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Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor

S100B protein is elevated in the brains of patients with early stages of Alzheimer's disease and Down's syndrome. S100A4 is correlated with the development of metastasis. Both proteins bind to p53 tumor suppressor. We found that both S100B and S100A4 bind to the tetramerization domain of p...

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Bibliografiske detaljer
Main Authors: Fernandez-Fernandez, Maria Rosario, Veprintsev, Dmitry B., Fersht, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC555715/
https://ncbi.nlm.nih.gov/pubmed/15781852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501459102
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