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Members of the S100 family bind p53 in two distinct ways

p53 binds to some members of the S100 family (S100B, S100A4, S100A2, and S100A1). We previously showed that both S100B and S100A4 bind to the p53 tetramerization domain, and consequently control its oligomerization state, but only S100B binds to the C-terminal negative regulatory domain (NRD). Here,...

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Bibliographic Details
Main Authors: Fernandez-Fernandez, Maria Rosario, Rutherford, Trevor J., Fersht, Alan R.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2548378/
https://ncbi.nlm.nih.gov/pubmed/18694925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.035527.108
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