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Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding
Oncogenic mutations inactivate the tumor suppressor p53 by lowering its stability or by weakening its binding to DNA. Alkylating agents that reactivate mutant p53 are currently being explored for cancer therapy. We have discovered ligands containing an α,β-unsaturated double bond, characteristic of...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009395/ https://ncbi.nlm.nih.gov/pubmed/20878668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.507 |
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