Stability of p53 Homologs

Most proteins have not evolved for maximal thermal stability. Some are only marginally stable, as for example, the DNA-binding domains of p53 and its homologs, whose kinetic and thermodynamic stabilities are strongly correlated. Here, we applied high-throughput methods using a real-time PCR thermocy...

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Bibliografske podrobnosti
Main Authors: Brandt, Tobias, Kaar, Joel L., Fersht, Alan R., Veprintsev, Dmitry B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480436/
https://ncbi.nlm.nih.gov/pubmed/23112865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047889
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