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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
The tumor suppressor p53 is mutationally inactivated in ≈50% of human cancers. Approximately one-third of the mutations lower the melting temperature of the protein, leading to its rapid denaturation. Small molecules that bind to those mutants and stabilize them could be effective anticancer drugs....
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2492497/ https://ncbi.nlm.nih.gov/pubmed/18650397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805326105 |
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