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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs
The DNA-binding domain of the tumor suppressor p53 is inactivated by mutation in ≈50% of human cancers. We have solved high-resolution crystal structures of several oncogenic mutants to investigate the structural basis of inactivation and provide information for designing drugs that may rescue inact...
Gorde:
| Egile Nagusiak: | , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2006
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1635156/ https://ncbi.nlm.nih.gov/pubmed/17015838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607286103 |
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