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Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition
Aggregation of destabilized mutants of the tumor suppressor p53 is a major route for its loss of activity. In order to assay drugs that inhibit aggregation of p53, we established the basic kinetics of aggregation of its core domain, using the mutant Y220C that has a mutation-induced, druggable cavit...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427094/ https://ncbi.nlm.nih.gov/pubmed/22869713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211550109 |
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