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First-order rate-determining aggregation mechanism of p53 and its implications
Aggregation of p53 is initiated by first-order processes that generate an aggregation-prone state with parallel pathways of major or partial unfolding. Here, we elaborate the mechanism and explore its consequences, beginning with the core domain and extending to the full-length p53 mutant Y220C. Pro...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427100/ https://ncbi.nlm.nih.gov/pubmed/22869710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211557109 |
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