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Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis
Many oncogenic mutations inactivate the tumor suppressor p53 by destabilizing it, leading to its rapid aggregation. Small molecule drugs are being developed to stabilize such mutants. The kinetics of aggregation of p53 is deceptively simple. The initial steps in the micromolar concentration range fo...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4345617/ https://ncbi.nlm.nih.gov/pubmed/25675526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500243112 |
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