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Φ-Value analysis and the nature of protein-folding transition states
Φ values are used to map structures of protein-folding transition states from changes in free energies of denaturation (ΔΔG(D-N)) and activation on mutation. A recent reappraisal proposed that Φ values for ΔΔG(D-N) < 1.7 kcal/mol are artifactual. On discarding such derived Φ values from published...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419542/ https://ncbi.nlm.nih.gov/pubmed/15150406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402684101 |
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