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Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding
Destabilized mutant p53s coaggregate with WT p53, p63, and p73 in cancer cell lines. We found that stoichiometric amounts of aggregation-prone mutants induced only small amounts of WT p53 to coaggregate, and preformed aggregates did not significantly seed the aggregation of bulk protein. Similarly,...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4345553/ https://ncbi.nlm.nih.gov/pubmed/25675527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500262112 |
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