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2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells
The tumor suppressor p53 has the most frequently mutated gene in human cancers. Many of p53’s oncogenic mutants are just destabilized and rapidly aggregate, and are targets for stabilization by drugs. We found certain 2-sulfonylpyrimidines, including one named PK11007, to be mild thiol alkylators wi...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5018792/ https://ncbi.nlm.nih.gov/pubmed/27551077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610421113 |
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