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Two sequence motifs from HIF-1α bind to the DNA-binding site of p53
There is evidence that hypoxia-inducible factor-1α (HIF-1α) interacts with the tumor suppressor p53. To characterize the putative interaction, we mapped the binding of the core domain of p53 (p53c) to an array of immobilized HIF-1α-derived peptides and found two peptide-sequence motifs that bound to...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124909/ https://ncbi.nlm.nih.gov/pubmed/12124396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122347199 |
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