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14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers

Activation of the tumour suppressor p53 on DNA damage involves post-translational modification by phosphorylation and acetylation. Phosphorylation of certain residues is critical for p53 stabilization and plays an important role in DNA-binding activity. The 14-3-3 family of proteins activates the DN...

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Библиографические подробности
Главные авторы: Rajagopalan, Sridharan, Jaulent, Agnes M., Wells, Mark, Veprintsev, Dmitry B., Fersht, Alan R.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566891/
https://ncbi.nlm.nih.gov/pubmed/18812399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn598
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