Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

The multidomain homotetrameric tumor suppressor p53 has two modes of binding dsDNA that are thought to be responsible for scanning and recognizing specific response elements (REs). The C termini bind nonspecifically to dsDNA. The four DNA-binding domains (DBDs) bind REs that have two symmetric 10 ba...

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Bibliografski detalji
Glavni autori: Melero, Roberto, Rajagopalan, Sridharan, Lázaro, Melisa, Joerger, Andreas C., Brandt, Tobias, Veprintsev, Dmitry B., Lasso, Gorka, Gil, David, Scheres, Sjors H. W., Carazo, José María, Fersht, Alan R., Valle, Mikel
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021029/
https://ncbi.nlm.nih.gov/pubmed/21178074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015520107
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