Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

The multidomain homotetrameric tumor suppressor p53 has two modes of binding dsDNA that are thought to be responsible for scanning and recognizing specific response elements (REs). The C termini bind nonspecifically to dsDNA. The four DNA-binding domains (DBDs) bind REs that have two symmetric 10 ba...

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Detaylı Bibliyografya
Asıl Yazarlar: Melero, Roberto, Rajagopalan, Sridharan, Lázaro, Melisa, Joerger, Andreas C., Brandt, Tobias, Veprintsev, Dmitry B., Lasso, Gorka, Gil, David, Scheres, Sjors H. W., Carazo, José María, Fersht, Alan R., Valle, Mikel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021029/
https://ncbi.nlm.nih.gov/pubmed/21178074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015520107
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