Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

The multidomain homotetrameric tumor suppressor p53 has two modes of binding dsDNA that are thought to be responsible for scanning and recognizing specific response elements (REs). The C termini bind nonspecifically to dsDNA. The four DNA-binding domains (DBDs) bind REs that have two symmetric 10 ba...

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Hlavní autoři: Melero, Roberto, Rajagopalan, Sridharan, Lázaro, Melisa, Joerger, Andreas C., Brandt, Tobias, Veprintsev, Dmitry B., Lasso, Gorka, Gil, David, Scheres, Sjors H. W., Carazo, José María, Fersht, Alan R., Valle, Mikel
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021029/
https://ncbi.nlm.nih.gov/pubmed/21178074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015520107
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