Quaternary structures of tumor suppressor p53 and a specific p53–DNA complex

The homotetrameric tumor suppressor p53 consists of folded core and tetramerization domains, linked and flanked by intrinsically disordered segments that impede structure analysis by x-ray crystallography and NMR. Here, we solved the quaternary structure of human p53 in solution by a combination of...

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Main Authors: Tidow, Henning, Melero, Roberto, Mylonas, Efstratios, Freund, Stefan M. V., Grossmann, J. Guenter, Carazo, José María, Svergun, Dmitri I., Valle, Mikel, Fersht, Alan R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2007
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941468/
https://ncbi.nlm.nih.gov/pubmed/17620598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705069104
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