Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

The multidomain homotetrameric tumor suppressor p53 has two modes of binding dsDNA that are thought to be responsible for scanning and recognizing specific response elements (REs). The C termini bind nonspecifically to dsDNA. The four DNA-binding domains (DBDs) bind REs that have two symmetric 10 ba...

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Bibliographic Details
Main Authors: Melero, Roberto, Rajagopalan, Sridharan, Lázaro, Melisa, Joerger, Andreas C., Brandt, Tobias, Veprintsev, Dmitry B., Lasso, Gorka, Gil, David, Scheres, Sjors H. W., Carazo, José María, Fersht, Alan R., Valle, Mikel
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021029/
https://ncbi.nlm.nih.gov/pubmed/21178074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015520107
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