From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design

Autor Yu, Li-Fang, Zhang, Han-Kun, Gunosewoyo, Hendra, Kozikowski, Alan P.
Vydáno 2012

Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol, a selective α4β2-nAChR partial agonist and promising antidepr...

Autor Yuan, Yang, Yu, Li-Fang, Qiu, Xi, Kozikowski, Alan P., van Breemen, Richard B.
Vydáno 2012

Effect of early enteral nutrition on outcomes of trauma patients requiring intensive care

Autor Peng-Fei Li, Yao-Li Wang, Yu-Li Fang, Ling Nan, Jian Zhou, Dan Zhang
Vydáno 2020-06-01

Bedside cardiopulmonary ultrasonography evaluates lung water content in very low-weight preterm neonates with patent ductus arteriosus

Autor Yu, Li-Fang, Xu, Chen-Ke, Zhao, Min, Niu, Lin, Huang, Xian-Mei, Zhang, Zhi-Qun
Vydáno v World J Clin Cases (2021)

Therapeutic Potential of Coumestan Pks13 Inhibitors for Tuberculosis

Autor Lun, Shichun, Xiao, Shiqi, Zhang, Wei, Wang, Shuangshuang, Gunosewoyo, Hendra, Yu, Li-Fang, Bishai, William R.
Vydáno v Antimicrob Agents Chemother (2021)

Recent Developments in Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors: Miniperspective

Autor Yu, Li-Fang, Zhang, Han-Kun, Caldarone, Barbara J., Eaton, J. Brek, Lukas, Ronald J., Kozikowski, Alan P.
Vydáno 2014

Discovery of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists Containing an Isoxazolylpyridine Ether Scaffold that Demonstrate Antidepress...

Autor Yu, Li-Fang, Eaton, J. Brek, Fedolak, Allison, Zhang, Han-Kun, Hanania, Taleen, Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Vydáno 2012

Identification of Novel α4β2-Nicotinic Acetylcholine Receptor (nAChR) Agonists Based on an Isoxazole Ether Scaffold that Demonstrate Antidepressant-like Activity

Autor Yu, Li-Fang, Tückmantel, Werner, Eaton, J. Brek, Caldarone, Barbara, Fedolak, Allison, Hanania, Taleen, Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Vydáno 2012

Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents

Autor Lin, Ying, Xing, Dong, Wu, Wen-Biao, Xu, Gao-Ya, Yu, Li-Fang, Tang, Jie, Zhou, Yu-Bo, Li, Jia, Yang, Fan
Vydáno v Molecules (2020)

Chemistry, Pharmacology, and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2- Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Prof...

Autor Zhang, Han-Kun, Yu, Li-Fang, Eaton, J. Brek, Whiteaker, Paul, Onajole, Oluseye K., Hanania, Taleen, Brunner, Daniela, Lukas, Ronald J., Kozikowski, Alan P.
Vydáno 2013

Synthesis and Biological Evaluation of Novel Hybrids of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists

Autor Zhang, Han-Kun, Eaton, J. Brek, Fedolak, Allison, Gunosewoyo, Hendra, Onajole, Oluseye K., Brunner, Dani, Lukas, Ronald J., Yu, Li-Fang, Kozikowski, Alan P.
Vydáno v Eur J Med Chem (2016)

Sigma-1 Receptor Agonist TS-157 Improves Motor Functional Recovery by Promoting Neurite Outgrowth and pERK in Rats with Focal Cerebral Ischemia

Autor Shi, Jun-Jie, Jiang, Qi-Hui, Zhang, Tian-Ning, Sun, Hao, Shi, Wen-Wen, Gunosewoyo, Hendra, Yang, Fan, Tang, Jie, Pang, Tao, Yu, Li-Fang
Vydáno v Molecules (2021)

Introducing nitrogen atoms to amidoalkylindoles: potent and selective cannabinoid type 2 receptor agonists with improved aqueous solubility

Autor Ji, Yue-Yang, Wang, Zhi-Long, Pei, Fang-Ning, Shi, Jun-Jie, Li, Jiao-Jiao, Gunosewoyo, Hendra, Yang, Fan, Tang, Jie, Xie, Xin, Yu, Li-Fang
Vydáno v Medchemcomm (2019)

Genome-wide analysis of SSR and ILP markers in trees: diversity profiling, alternate distribution, and applications in duplication

Autor Xia, Xinyao, Luan, Lin Lin, Qin, Guanghua, Yu, Li Fang, Wang, Zhi Wei, Dong, Wan Chen, Song, Yumin, Qiao, Yuling, Zhang, Xian Sheng, Sang, Ya Lin, Yang, Long
Vydáno v Sci Rep (2017)

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

Autor Pang, Tao, Zhang, Zhen-Shan, Gu, Min, Qiu, Bei-Ying, Yu, Li-Fang, Cao, Peng-Rong, Shao, Wei, Su, Ming-Bo, Li, Jing-Ya, Nan, Fa-Jun, Li, Jia
Vydáno 2008

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators

Autor Yu, Li-Fang, Li, Yuan-Yuan, Su, Ming-Bo, Zhang, Mei, Zhang, Wei, Zhang, Li-Na, Pang, Tao, Zhang, Run-Tao, Liu, Bing, Li, Jing-Ya, Li, Jia, Nan, Fa-Jun
Vydáno 2013

Discovery of Isoxazole Analogs of Sazetidine-A as Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists for the Treatment of Depression

Autor Liu, Jianhua, Yu, Li-Fang, Eaton, J. Brek, Caldarone, Barbara, Cavino, Katie, Ruiz, Christina, Terry, Matthew, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Lowe, David A., Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Vydáno 2011

Sonographic Alteration of Basal Ganglia in Different Forms of Primary Focal Dystonia: A Cross-sectional Study

Autor Zhang, Ying, Zhang, Ying-Chun, Sheng, Yu-Jing, Chen, Xiao-Fang, Wang, Cai-Shan, Ma, Qi, Chen, Han-Bing, Yu, Li-Fang, Mao, Cheng-Jie, Xiong, Kang-Ping, Luo, Wei-Feng, Liu, Chun-Feng
Vydáno v Chin Med J (Engl) (2016)

The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-...

Autor Yu, Li-Fang, Brek Eaton, J, Zhang, Han-Kun, Sabath, Emily, Hanania, Taleen, Li, Guan-Nan, van Breemen, Richard B, Whiteaker, Paul, Liu, Qiang, Wu, Jie, Chang, Yong-Chang, Lukas, Ronald J, Brunner, Dani, Kozikowski, Alan P
Vydáno 2014

Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile

Autor Zhang, Hankun, Tückmantel, Werner, Eaton, J. Brek, Yuen, Po-wai, Yu, Li-Fang, Bajjuri, Krishna Mohan, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Caldarone, Barbara, Paterson, Neil E., Lowe, David A., Brunner, Daniela, Lukas, Ronald J., Kozikowski, Alan P.
Vydáno 2012