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Synthesis and Biological Evaluation of Novel Hybrids of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists

We previously reported the cyclopropylpyridine and isoxazolylpyridine ether scaffolds to be versatile building blocks for creating potent α4β2 nicotinic acetylcholine receptor (nAChR) partial agonists with excellent selectivity over the α3β4 subtype. In our continued efforts to develop therapeutic n...

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Bibliografiske detaljer
Udgivet i:Eur J Med Chem
Main Authors: Zhang, Han-Kun, Eaton, J. Brek, Fedolak, Allison, Gunosewoyo, Hendra, Onajole, Oluseye K., Brunner, Dani, Lukas, Ronald J., Yu, Li-Fang, Kozikowski, Alan P.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097879/
https://ncbi.nlm.nih.gov/pubmed/27639361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.09.016
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