Identification of Novel α4β2-Nicotinic Acetylcholine Receptor (nAChR) Agonists Based on an Isoxazole Ether Scaffold that Demonstrate Antidepressant-like Activity

There is considerable evidence to support the hypothesis that the blockade of nAChR is responsible for the antidepressant action of nicotinic ligands. The nicotinic acetylcholine receptor (nAChR) antagonist, mecamylamine, has been shown to be an effective add-on in patients that do not respond to se...

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Hlavní autoři: Yu, Li-Fang, Tückmantel, Werner, Eaton, J. Brek, Caldarone, Barbara, Fedolak, Allison, Hanania, Taleen, Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272775/
https://ncbi.nlm.nih.gov/pubmed/22148173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201301h
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