Highthroughtput analysis of behavior for drug discovery

Por Alexandrov, Vadim, Brunner, Dani, Hanania, Taleen, Leahy, Emer
Publicado no Eur J Pharmacol (2015)

Noribogaine reduces nicotine self-administration in rats

Por Chang, Qing, Hanania, Taleen, Mash, Deborah C, Maillet, Emeline L
Publicado no J Psychopharmacol (2015)

Rapid, Computer Vision-Enabled Murine Screening System Identifies Neuropharmacological Potential of Two New Mechanisms

Por Roberds, Steven L., Filippov, Igor, Alexandrov, Vadim, Hanania, Taleen, Brunner, Dani
Publicado em 2011

Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents

Por Paterson, Neil E., Fedolak, Allison, Olivier, Berend, Hanania, Taleen, Ghavami, Afshin, Caldarone, Barbara
Publicado em 2010

Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3β Inhibitor: a Superior Neuroprotective Pyrazolone Showing Antimania Effects

Por Chen, Wenwen, Gaisina, Irina N., Gunosewoyo, Hendra, Malekiani, Sam A., Hanania, Taleen, Kozikowski, Alan P.
Publicado em 2011

Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress

Por Lorsch, Zachary S., Ambesi-Impiombato, Alberto, Zenowich, Rebecca, Morganstern, Irene, Leahy, Emer, Bansal, Mukesh, Nestler, Eric J., Hanania, Taleen
Publicado no Biol Psychiatry (2020)

Mouse model systems of autism spectrum disorder: Replicability and informatics signature

Por Kabitzke, Patricia, Morales, Diana, He, Dansha, Cox, Kimberly, Sutphen, Jane, Thiede, Lucinda, Sabath, Emily, Hanania, Taleen, Biemans, Barbara, Brunner, Daniela
Publicado no Genes Brain Behav (2020)

Discovery of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists Containing an Isoxazolylpyridine Ether Scaffold that Demonstrate Antidepress...

Por Yu, Li-Fang, Eaton, J. Brek, Fedolak, Allison, Zhang, Han-Kun, Hanania, Taleen, Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Publicado em 2012

Characterization of Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as Stimulators of Steroidogenesis

Por Gunosewoyo, Hendra, Midzak, Andrew, Gaisina, Irina N., Sabath, Emily V., Fedolak, Allison, Hanania, Taleen, Brunner, Dani, Papadopoulos, Vassilios, Kozikowski, Alan P.
Publicado em 2013

Identification of Novel α4β2-Nicotinic Acetylcholine Receptor (nAChR) Agonists Based on an Isoxazole Ether Scaffold that Demonstrate Antidepressant-like Activity

Por Yu, Li-Fang, Tückmantel, Werner, Eaton, J. Brek, Caldarone, Barbara, Fedolak, Allison, Hanania, Taleen, Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Publicado em 2012

Chemistry, Pharmacology, and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2- Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Prof...

Por Zhang, Han-Kun, Yu, Li-Fang, Eaton, J. Brek, Whiteaker, Paul, Onajole, Oluseye K., Hanania, Taleen, Brunner, Daniela, Lukas, Ronald J., Kozikowski, Alan P.
Publicado em 2013

Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain

Por Kwan, Mei Yee, Choo, Anthony, Hanania, Taleen, Ghavami, Afshin, Beltran, Jose, Shea, John, Barboza, Amidi, Hu, Andrew, Fowler, Marcie, Neelagiri, Venugopal Rao, Sucholeiki, Irving
Publicado no Int J Mol Sci (2019)

Effect of a novel, orally active matrix metalloproteinease-2 and-9 inhibitor in spinal and trigeminal rat models of neuropathic pain

Por Henry, Michael A., Fairchild, Dara D., Patil, Mayur J., Hanania, Taleen, Hain, Heather S., Davis, Scott F., Malekiani, Sam A., Hu, Andrew, Sucholeiki, Roy, Nix, Darrell, Sucholeiki, Irving
Publicado no J Oral Facial Pain Headache (2015)

Dissociation between duration of action in the forced swim test and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380

Por Caldarone, Barbara J., Wang, Daguang, Paterson, Neil E., Manzano, Michael, Fedolak, Allison, Cavino, Katie, Kwan, Mei, Hanania, Taleen, Chellappan, Sheela K., Kozikowski, Alan P., Olivier, Berend, Picciotto, Marina R., Ghavami, Afshin
Publicado em 2011

Functional Uncoupling of Adenosine A(2A) Receptors and Reduced Response to Caffeine in Mice Lacking Dopamine D(2)Receptors

Por Zahniser, Nancy R., Simosky, Johanna K., Mayfield, R. Dayne, Negri, Cori A., Hanania, Taleen, Larson, Gaynor A., Kelly, Michele A., Grandy, David K., Rubinstein, Marcelo, Low, Malcolm J., Fredholm, Bertil B.
Publicado no J Neurosci (2000)

SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition

Por Hanson, Jesse E., La, Hank, Plise, Emile, Chen, Yung-Hsiang, Ding, Xiao, Hanania, Taleen, Sabath, Emily V., Alexandrov, Vadim, Brunner, Dani, Leahy, Emer, Steiner, Pascal, Liu, Lichuan, Scearce-Levie, Kimberly, Zhou, Qiang
Publicado em 2013

Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder

Por Brunner, Daniela, Kabitzke, Patricia, He, Dansha, Cox, Kimberly, Thiede, Lucinda, Hanania, Taleen, Sabath, Emily, Alexandrov, Vadim, Saxe, Michael, Peles, Elior, Mills, Alea, Spooren, Will, Ghosh, Anirvan, Feliciano, Pamela, Benedetti, Marta, Luo Clayton, Alice, Biemans, Barbara
Publicado no PLoS One (2015)

The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-...

Por Yu, Li-Fang, Brek Eaton, J, Zhang, Han-Kun, Sabath, Emily, Hanania, Taleen, Li, Guan-Nan, van Breemen, Richard B, Whiteaker, Paul, Liu, Qiang, Wu, Jie, Chang, Yong-Chang, Lukas, Ronald J, Brunner, Dani, Kozikowski, Alan P
Publicado em 2014

Insights into the Structural Determinants Required for High Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors; An Integrated Appr...

Por Zhang, Han-Kun, Eaton, J. Brek, Yu, Li-Fang, Nys, Mieke, Mazzolari, Angelica, van Elk, René, Smit, August B., Alexandrov, Vadim, Hanania, Taleen, Sabath, Emily, Fedolak, Allison, Brunner, Daniela, Lukas, Ronald J., Vistoli, Giulio, Ulens, Chris, Kozikowski, Alan P.
Publicado em 2012