From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design

Por Yu, Li-Fang, Zhang, Han-Kun, Gunosewoyo, Hendra, Kozikowski, Alan P.
Publicado em 2012

Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol, a selective α4β2-nAChR partial agonist and promising antidepr...

Por Yuan, Yang, Yu, Li-Fang, Qiu, Xi, Kozikowski, Alan P., van Breemen, Richard B.
Publicado em 2012

Recent Developments in Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors: Miniperspective

Por Yu, Li-Fang, Zhang, Han-Kun, Caldarone, Barbara J., Eaton, J. Brek, Lukas, Ronald J., Kozikowski, Alan P.
Publicado em 2014

Discovery of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists Containing an Isoxazolylpyridine Ether Scaffold that Demonstrate Antidepress...

Por Yu, Li-Fang, Eaton, J. Brek, Fedolak, Allison, Zhang, Han-Kun, Hanania, Taleen, Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Publicado em 2012

Identification of Novel α4β2-Nicotinic Acetylcholine Receptor (nAChR) Agonists Based on an Isoxazole Ether Scaffold that Demonstrate Antidepressant-like Activity

Por Yu, Li-Fang, Tückmantel, Werner, Eaton, J. Brek, Caldarone, Barbara, Fedolak, Allison, Hanania, Taleen, Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Publicado em 2012

Chemistry, Pharmacology, and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2- Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Prof...

Por Zhang, Han-Kun, Yu, Li-Fang, Eaton, J. Brek, Whiteaker, Paul, Onajole, Oluseye K., Hanania, Taleen, Brunner, Daniela, Lukas, Ronald J., Kozikowski, Alan P.
Publicado em 2013

Synthesis and Biological Evaluation of Novel Hybrids of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists

Por Zhang, Han-Kun, Eaton, J. Brek, Fedolak, Allison, Gunosewoyo, Hendra, Onajole, Oluseye K., Brunner, Dani, Lukas, Ronald J., Yu, Li-Fang, Kozikowski, Alan P.
Publicado no Eur J Med Chem (2016)

Genome-wide analysis of SSR and ILP markers in trees: diversity profiling, alternate distribution, and applications in duplication

Por Xia, Xinyao, Luan, Lin Lin, Qin, Guanghua, Yu, Li Fang, Wang, Zhi Wei, Dong, Wan Chen, Song, Yumin, Qiao, Yuling, Zhang, Xian Sheng, Sang, Ya Lin, Yang, Long
Publicado no Sci Rep (2017)

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

Por Pang, Tao, Zhang, Zhen-Shan, Gu, Min, Qiu, Bei-Ying, Yu, Li-Fang, Cao, Peng-Rong, Shao, Wei, Su, Ming-Bo, Li, Jing-Ya, Nan, Fa-Jun, Li, Jia
Publicado em 2008

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators

Por Yu, Li-Fang, Li, Yuan-Yuan, Su, Ming-Bo, Zhang, Mei, Zhang, Wei, Zhang, Li-Na, Pang, Tao, Zhang, Run-Tao, Liu, Bing, Li, Jing-Ya, Li, Jia, Nan, Fa-Jun
Publicado em 2013

Discovery of Isoxazole Analogs of Sazetidine-A as Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists for the Treatment of Depression

Por Liu, Jianhua, Yu, Li-Fang, Eaton, J. Brek, Caldarone, Barbara, Cavino, Katie, Ruiz, Christina, Terry, Matthew, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Lowe, David A., Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Publicado em 2011

Sonographic Alteration of Basal Ganglia in Different Forms of Primary Focal Dystonia: A Cross-sectional Study

Por Zhang, Ying, Zhang, Ying-Chun, Sheng, Yu-Jing, Chen, Xiao-Fang, Wang, Cai-Shan, Ma, Qi, Chen, Han-Bing, Yu, Li-Fang, Mao, Cheng-Jie, Xiong, Kang-Ping, Luo, Wei-Feng, Liu, Chun-Feng
Publicado no Chin Med J (Engl) (2016)

The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-...

Por Yu, Li-Fang, Brek Eaton, J, Zhang, Han-Kun, Sabath, Emily, Hanania, Taleen, Li, Guan-Nan, van Breemen, Richard B, Whiteaker, Paul, Liu, Qiang, Wu, Jie, Chang, Yong-Chang, Lukas, Ronald J, Brunner, Dani, Kozikowski, Alan P
Publicado em 2014

Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile

Por Zhang, Hankun, Tückmantel, Werner, Eaton, J. Brek, Yuen, Po-wai, Yu, Li-Fang, Bajjuri, Krishna Mohan, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Caldarone, Barbara, Paterson, Neil E., Lowe, David A., Brunner, Daniela, Lukas, Ronald J., Kozikowski, Alan P.
Publicado em 2012

Insights into the Structural Determinants Required for High Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors; An Integrated Appr...

Por Zhang, Han-Kun, Eaton, J. Brek, Yu, Li-Fang, Nys, Mieke, Mazzolari, Angelica, van Elk, René, Smit, August B., Alexandrov, Vadim, Hanania, Taleen, Sabath, Emily, Fedolak, Allison, Brunner, Daniela, Lukas, Ronald J., Vistoli, Giulio, Ulens, Chris, Kozikowski, Alan P.
Publicado em 2012