Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile

Despite their discovery in the early 20th century and intensive study over the last twenty years, nicotinic acetylcholine receptors (nAChRs) are still far from being well understood. Only a few chemical entities targeting nAChRs are currently undergoing clinical trials, and even fewer have reached t...

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Detalhes bibliográficos
Main Authors: Zhang, Hankun, Tückmantel, Werner, Eaton, J. Brek, Yuen, Po-wai, Yu, Li-Fang, Bajjuri, Krishna Mohan, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Caldarone, Barbara, Paterson, Neil E., Lowe, David A., Brunner, Daniela, Lukas, Ronald J., Kozikowski, Alan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292870/
https://ncbi.nlm.nih.gov/pubmed/22171543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201157c
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