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Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators
[Image: see text] Adenosine 5′-monophosphate-activated protein kinase (AMPK) is emerging as a promising drug target for its regulatory function in both glucose and lipid metabolism. Compound PT1 (5) was originally identified from high throughput screening as a small molecule activator of AMPK throug...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2013
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027511/ https://ncbi.nlm.nih.gov/pubmed/24900695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400028q |
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