Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators

[Image: see text] Adenosine 5′-monophosphate-activated protein kinase (AMPK) is emerging as a promising drug target for its regulatory function in both glucose and lipid metabolism. Compound PT1 (5) was originally identified from high throughput screening as a small molecule activator of AMPK throug...

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Detalhes bibliográficos
Main Authors: Yu, Li-Fang, Li, Yuan-Yuan, Su, Ming-Bo, Zhang, Mei, Zhang, Wei, Zhang, Li-Na, Pang, Tao, Zhang, Run-Tao, Liu, Bing, Li, Jing-Ya, Li, Jia, Nan, Fa-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027511/
https://ncbi.nlm.nih.gov/pubmed/24900695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400028q
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