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Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors
AMP-activated protein kinase (AMPK) is a central metabolic regulator that promotes cancer growth and survival under hypoxia and plays a role in the maintenance of cancer stem cells. A major challenge to interrogating the potential of targeting AMPK in cancer is the lack of potent and selective small...
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| Опубликовано в: : | Eur J Med Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7409528/ https://ncbi.nlm.nih.gov/pubmed/32334266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112316 |
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