Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors

In many forms of cancer the signal transducer and activator of transcription 3 (STAT3) transcription factor remains constitutively active, driving cancer survival and progression. The critical role of STAT3 in tumorigenesis has prompted a campaign of drug discovery programs to identify small molecul...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Furtek, Steffanie L., Matheson, Christopher J., Backos, Donald S., Reigan, Philip
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363639/
https://ncbi.nlm.nih.gov/pubmed/27793003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12868
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