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Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors

Pituitary tumors of the gonadotrope lineage are often large and invasive, resulting in hypopituitarism. No medical treatments are currently available. Using a combined genetic and genomic screen of individual human gonadotrope pituitary tumor samples, we recently identified the mammalian sterile-20...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Cancer Ther
Main Authors: Xiong, Weipeng, Matheson, Christopher J., Xu, Mei, Backos, Donald S., Mills, Taylor S., Salian-Mehta, Smita, Kiseljak-Vassiliades, Katja, Reigan, Philip, Wierman, Margaret E.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820170/
https://ncbi.nlm.nih.gov/pubmed/26721946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0703
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