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The Tumor Suppressor RASSF1A Prevents Dephosphorylation of the Mammalian STE20-like Kinases MST1 and MST2

The RASSF1A tumor suppressor protein interacts with the pro-apoptotic mammalian STE20-like kinases MST1 and MST2 and induces their autophosphorylation and activation, but the mechanism of how RASSF1A activates MST1/2 is unclear. Okadaic acid treatment and PP2A knockdown promoted MST1/2 phosphorylati...

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Bibliografske podrobnosti
Main Authors: Guo, Cai, Zhang, Xiaoying, Pfeifer, Gerd P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057778/
https://ncbi.nlm.nih.gov/pubmed/21199877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.178210
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