Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Por Sausen, Mark, Phallen, Jillian, Adleff, Vilmos, Jones, Siân, Leary, Rebecca J., Barrett, Michael T., Anagnostou, Valsamo, Parpart-Li, Sonya, Murphy, Derek, Li, Qing Kay, Hruban, Carolyn A., Scharpf, Rob, White, James R., O'Dwyer, Peter J., Allen, Peter J., Eshleman, James R., Thompson, Craig B., Klimstra, David S., Linehan, David C., Maitra, Anirban, Hruban, Ralph H., Diaz, Luis A., Von Hoff, Daniel D., Johansen, Julia S., Drebin, Jeffrey A., Velculescu, Victor E.
Publicado no Nat Commun (2015)

Direct Sequencing of Arabidopsis thaliana RNA Reveals Patterns of Cleavage and Polyadenylation

Por Sherstnev, Alexander, Duc, Céline, Cole, Christian, Zacharaki, Vasiliki, Hornyik, Csaba, Ozsolak, Fatih, Milos, Patrice M., Barton, Geoffrey J., Simpson, Gordon G.
Publicado em 2012

PRESTO-TANGO: an open-source resource for interrogation of the druggable human GPCR-ome

Por Kroeze, W.K., Sassano, M.F., Huang, X.-P., Lansu, K., McCorvy, J.D., Giguere, P.M., Sciaky, N., Roth, B.L.
Publicado no Nat Struct Mol Biol (2015)

A Broad Nanoparticle-Based Strategy for Tumor Imaging by Nonlinear Amplification of Microenvironment Signals

Por Wang, Yiguang, Zhou, Kejin, Huang, Gang, Hensley, Chris, Huang, Xiaonan, Ma, Xinpeng, Zhao, Tian, Sumer, Baran D., DeBerardinis, Ralph J., Gao, Jinming
Publicado em 2013

Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging

Por Tichauer, Kenneth M., Samkoe, Kimberley S., Gunn, Jason R., Kanick, Stephen C., Hoopes, P. Jack, Barth, Richard J., Kaufman, Peter A., Hasan, Tayyaba, Pogue, Brian W.
Publicado no Nat Med (2014)

Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers

Por McCreery, Melissa Q, Halliwill, Kyle D, Chin, Douglas, Delrosario, Reyno, Hirst, Gillian, Vuong, Peter, Jen, Kuang-Yu, Hewinson, James, Adams, David J, Balmain, Allan
Publicado no Nat Med (2015)

Dynamics of metatranscription in the inflammatory bowel disease gut microbiome

Por Schirmer, Melanie, Franzosa, Eric A., Lloyd-Price, Jason, McIver, Lauren J., Schwager, Randall, Poon, Tiffany W., Ananthakrishnan, Ashwin N., Andrews, Elizabeth, Barron, Gildardo, Lake, Kathleen, Prasad, Mahadev, Sauk, Jenny, Stevens, Betsy, Wilson, Robin G., Braun, Jonathan, Denson, Lee A., Kugathasan, Subra, McGovern, Dermot P.B., Vlamakis, Hera, Xavier, Ramnik J., Huttenhower, Curtis
Publicado no Nat Microbiol (2018)

The Role of Distant Mutations and Allosteric Regulation on LovD Active Site Dynamics

Por Jiménez-Osés, Gonzalo, Osuna, Sílvia, Gao, Xue, Sawaya, Michael R., Gilson, Lynne, Collier, Steven J., Huisman, Gjalt W., Yeates, Todd O., Tang, Yi, Houk, K. N.
Publicado em 2014

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic (13)C magnetic resonance spectroscopy

Por Befroy, Douglas E., Perry, Rachel J., Jain, Nimit, Dufour, Sylvie, Cline, Gary W., Trimmer, Jeff, Brosnan, Julia, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.
Publicado em 2013

Peptidomic discovery of short open reading frame-encoded peptides in human cells

Por Slavoff, Sarah A., Mitchell, Andrew J., Schwaid, Adam G., Cabili, Moran N., Ma, Jiao, Levin, Joshua Z., Karger, Amir D., Budnik, Bogdan A., Rinn, John L., Saghatelian, Alan
Publicado em 2012

A novel, primate-specific, brain isoform of KCNH2 impacts cortical physiology, cognition, neuronal repolarization and risk for schizophrenia

Por Huffaker, Stephen J., Chen, Jingshan, Nicodemus, Kristin K., Sambataro, Fabio, Yang, Feng, Mattay, Venkata, Lipska, Barbara K., Hyde, Thomas M., Song, Jian, Rujescu, Daniel, Giegling, Ina, Mayilyan, Karine, Proust, Morgan J., Soghoyan, Armen, Caforio, Grazia, Callicott, Joseph H., Bertolino, Alessandro, Meyer-Lindenberg, Andreas, Chang, Jay, Ji, Yuanyuan, Egan, Michael F., Goldberg, Terry E., Kleinman, Joel E., Lu, Bai, Weinberger, Daniel R.
Publicado em 2009

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration

Por Orgaz, Jose L., Pandya, Pahini, Dalmeida, Rimple, Karagiannis, Panagiotis, Sanchez-Laorden, Berta, Viros, Amaya, Albrengues, Jean, Nestle, Frank O., Ridley, Anne J., Gaggioli, Cedric, Marais, Richard, Karagiannis, Sophia N., Sanz-Moreno, Victoria
Publicado em 2014

Rates, Distribution, and Implications of Post-zygotic Mosaic Mutations in Autism Spectrum Disorder

Por Lim, Elaine T., Uddin, Mohammed, De Rubeis, Silvia, Chan, Yingleong, Kamumbu, Anne S., Zhang, Xiaochang, D'Gama, Alissa, Kim, Sonia N., Hill, Robert Sean, Goldberg, Arthur P., Poultney, Christopher, Minshew, Nancy J., Kushima, Itaru, Aleksic, Branko, Ozaki, Norio, Parellada, Mara, Arango, Celso, Penzol, Maria J., Carracedo, Angel, Kolevzon, Alexander, Hultman, Christina M., Weiss, Lauren A., Fromer, Menachem, Chiocchetti, Andreas G., Freitag, Christine M., Church, George M., Scherer, Stephen W., Buxbaum, Joseph D., Walsh, Christopher A.
Publicado no Nat Neurosci (2017)

Systemic depletion of serum l-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice

Por Cramer, Shira L., Saha, Achinto, Liu, Jinyun, Tadi, Surendar, Tiziani, Stefano, Yan, Wupeng, Triplett, Kendra, Lamb, Candice, Alters, Susan E., Rowlinson, Scott, Zhang, Yan Jessie, Keating, Michael J., Huang, Peng, DiGiovanni, John, Georgiou, George, Stone, Everett
Publicado no Nat Med (2016)

Mutational Landscape of Metastatic Cancer Revealed from Prospective Clinical Sequencing of 10,000 Patients

Por Zehir, Ahmet, Benayed, Ryma, Shah, Ronak H., Syed, Aijazuddin, Middha, Sumit, Kim, Hyunjae R., Srinivasan, Preethi, Gao, Jianjiong, Chakravarty, Debyani, Devlin, Sean M., Hellmann, Matthew D., Barron, David A., Schram, Alison M., Hameed, Meera, Dogan, Snjezana, Ross, Dara S., Hechtman, Jaclyn F., DeLair, Deborah F., Yao, JinJuan, Mandelker, Diana L., Cheng, Donavan T., Chandramohan, Raghu, Mohanty, Abhinita S., Ptashkin, Ryan N., Jayakumaran, Gowtham, Prasad, Meera, Syed, Mustafa H., Rema, Anoop Balakrishnan, Liu, Zhen Y., Nafa, Khedoudja, Borsu, Laetitia, Sadowska, Justyna, Casanova, Jacklyn, Bacares, Ruben, Kiecka, Iwona J., Razumova, Anna, Son, Julie B., Stewart, Lisa, Baldi, Tessara, Mullaney, Kerry A., Al-Ahmadie, Hikmat, Vakiani, Efsevia, Abeshouse, Adam A., Penson, Alexander V., Jonsson, Philip, Camacho, Niedzica, Chang, Matthew T., Won, Helen H., Gross, Benjamin E., Kundra, Ritika, Heins, Zachary J., Chen, Hsiao-Wei, Phillips, Sarah, Zhang, Hongxin, Wang, Jiaojiao, Ochoa, Angelica, Wills, Jonathan, Eubank, Michael, Thomas, Stacy B., Gardos, Stuart M., Reales, Dalicia N., Galle, Jesse, Durany, Robert, Cambria, Roy, Abida, Wassim, Cercek, Andrea, Feldman, Darren R., Gounder, Mrinal M., Hakimi, A. Ari, Harding, James J., Iyer, Gopa, Janjigian, Yelena Y., Jordan, Emmet J., Kelly, Ciara M., Lowery, Maeve A., Morris, Luc G.T., Omuro, Antonio M., Raj, Nitya, Razavi, Pedram, Shoushtari, Alexander N., Shukla, Neerav, Soumerai, Tara E., Varghese, Anna M., Yaeger, Rona, Coleman, Jonathan, Bochner, Bernard, Riely, Gregory J., Saltz, Leonard B., Scher, Howard I., Sabbatini, Paul J., Robson, Mark E., Klimstra, David S., Taylor, Barry S., Baselga, Jose, Schultz, Nikolaus, Hyman, David M., Arcila, Maria E., Solit, David B., Ladanyi, Marc, Berger, Michael F.
Publicado no Nat Med (2017)

Whole Genome Sequence-Based Analysis of a Model Complex Trait, High Density Lipoprotein Cholesterol

Por Morrison, Alanna C., Voorman, Arend, Johnson, Andrew D., Liu, Xiaoming, Yu, Jin, Li, Alexander, Muzny, Donna, Yu, Fuli, Rice, Kenneth, Zhu, Chengsong, Bis, Joshua, Heiss, Gerardo, O’Donnell, Christopher J., Psaty, Bruce M., Cupples, L. Adrienne, Gibbs, Richard, Boerwinkle, Eric
Publicado em 2013

Phased Diploid Genome Assembly with Single Molecule Real-Time Sequencing

Por Chin, Chen-Shan, Peluso, Paul, Sedlazeck, Fritz J., Nattestad, Maria, Concepcion, Gregory T., Clum, Alicia, Dunn, Christopher, O’Malley, Ronan, Figueroa-Balderas, Rosa, Morales-Cruz, Abraham, Cramer, Grant R., Delledonne, Massimo, Luo, Chongyuan, Ecker, Joseph R., Cantu, Dario, Rank, David R., Schatz, Michael C.
Publicado no Nat Methods (2016)

Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

Por Nik-Zainal, Serena, Wedge, David C., Alexandrov, Ludmil B., Petljak, Mia, Butler, Adam P., Bolli, Niccolo, Davies, Helen R., Knappskog, Stian, Martin, Sancha, Papaemmanuil, Elli, Ramakrishna, Manasa, Shlien, Adam, Simonic, Ingrid, Xue, Yali, Tyler-Smith, Chris, Campbell, Peter J., Stratton, Michael R.
Publicado em 2014

Genomics of Loa loa, a Wolbachia-free filarial parasite of humans

Por Desjardins, Christopher A., Cerqueira, Gustavo C., Goldberg, Jonathan M., Hotopp, Julie C. Dunning, Haas, Brian J., Zucker, Jeremy, Ribeiro, Jose’ M.C., Saif, Sakina, Levin, Joshua Z., Fan, Lin, Zeng, Qiandong, Russ, Carsten, Wortman, Jennifer R., Fink, Doran L., Birren, Bruce W., Nutman, Thomas B.
Publicado no Nat Genet (2013)

African origin of the malaria parasite Plasmodium vivax

Por Liu, Weimin, Li, Yingying, Shaw, Katharina S., Learn, Gerald H., Plenderleith, Lindsey J., Malenke, Jordan A., Sundararaman, Sesh A., Ramirez, Miguel A., Crystal, Patricia A., Smith, Andrew G., Bibollet-Ruche, Frederic, Ayouba, Ahidjo, Locatelli, Sabrina, Esteban, Amandine, Mouacha, Fatima, Guichet, Emilande, Butel, Christelle, Ahuka-Mundeke, Steve, Inogwabini, Bila-Isia, Ndjango, Jean-Bosco N., Speede, Sheri, Sanz, Crickette M., Morgan, David B., Gonder, Mary K., Kranzusch, Philip J., Walsh, Peter D., Georgiev, Alexander V., Muller, Martin N., Piel, Alex K., Stewart, Fiona A., Wilson, Michael L., Pusey, Anne E., Cui, Liwang, Wang, Zenglei, Färnert, Anna, Sutherland, Colin J., Nolder, Debbie, Hart, John A., Hart, Terese B., Bertolani, Paco, Gillis, Amethyst, LeBreton, Matthew, Tafon, Babila, Kiyang, John, Djoko, Cyrille F., Schneider, Bradley S., Wolfe, Nathan D., Mpoudi-Ngole, Eitel, Delaporte, Eric, Carter, Richard, Culleton, Richard L., Shaw, George M., Rayner, Julian C., Peeters, Martine, Hahn, Beatrice H., Sharp, Paul M.
Publicado em 2014