PRESTO-TANGO: an open-source resource for interrogation of the druggable human GPCR-ome

G protein-coupled receptors (GPCRs) are essential mediators of cellular signaling and important targets of drug action. Of the approximately 350 non-olfactory human GPCRs, more than 100 are still considered “orphans” as their endogenous ligand(s) remain unknown. Here, we describe a unique open-sourc...

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Detalles Bibliográficos
Publicado en:Nat Struct Mol Biol
Autores principales: Kroeze, W.K., Sassano, M.F., Huang, X.-P., Lansu, K., McCorvy, J.D., Giguere, P.M., Sciaky, N., Roth, B.L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424118/
https://ncbi.nlm.nih.gov/pubmed/25895059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3014
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