A unified haplotype-based method for accurate and comprehensive variant calling

per Cooke, Daniel P., Wedge, David C., Lunter, Gerton
Publicat a Nat Biotechnol (2021)

Principles of Reconstructing the Subclonal Architecture of Cancers

per Dentro, Stefan C., Wedge, David C., Van Loo, Peter
Publicat a Cold Spring Harb Perspect Med (2017)

Re-evaluating experimental validation in the Big Data Era: a conceptual argument

per Jafari, Mohieddin, Guan, Yuanfang, Wedge, David C., Ansari-Pour, Naser
Publicat a Genome Biol (2021)

Analysis of a complete DNA–protein affinity landscape

per Rowe, William, Platt, Mark, Wedge, David C., Day, Philip J., Kell, Douglas B., Knowles, Joshua
Publicat 2010

Deciphering Signatures of Mutational Processes Operative in Human Cancer

per Alexandrov, Ludmil B., Nik-Zainal, Serena, Wedge, David C., Campbell, Peter J., Stratton, Michael R.
Publicat 2013

FDRAnalysis: A tool for the integrated analysis of tandem mass spectrometry identification results from multiple search engines

per Wedge, David C, Krishna, Ritesh, Blackhurst, Paul, Siepen, Jennifer A, Jones, Andrew R., Hubbard, Simon J.
Publicat 2011

CONSeQuence: Prediction of Reference Peptides for Absolute Quantitative Proteomics Using Consensus Machine Learning Approaches

per Eyers, Claire E., Lawless, Craig, Wedge, David C., Lau, King Wai, Gaskell, Simon J., Hubbard, Simon J.
Publicat 2011

Reference bias in the Illumina Isaac aligner

per Cornish, Alex J, Chubb, Daniel, Frangou, Anna, Hoang, Phuc H, Kaiser, Martin, Wedge, David C, Houlston, Richard S
Publicat a Bioinformatics (2020)

Clock-like mutational processes in human somatic cells

per Alexandrov, Ludmil B., Jones, Philip H., Wedge, David C., Sale, Julian E., Campbell, Peter J., Nik-Zainal, Serena, Stratton, Michael R.
Publicat a Nat Genet (2015)

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

per Knight, Christopher G., Platt, Mark, Rowe, William, Wedge, David C., Khan, Farid, Day, Philip J. R., McShea, Andy, Knowles, Joshua, Kell, Douglas B.
Publicat 2009

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

per Brown, Marie, Wedge, David C., Goodacre, Royston, Kell, Douglas B., Baker, Philip N., Kenny, Louise C., Mamas, Mamas A., Neyses, Ludwig, Dunn, Warwick B.
Publicat 2011

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

per Brown, Marie, Wedge, David C., Goodacre, Royston, Kell, Douglas B., Baker, Philip N., Kenny, Louise C., Mamas, Mamas A., Neyses, Ludwig, Dunn, Warwick B.
Publicat 2012

A practical guide to cancer subclonal reconstruction from DNA sequencing

per Tarabichi, Maxime, Salcedo, Adriana, Deshwar, Amit G., Leathlobhair, Máire Ni, Wintersinger, Jeff, Wedge, David C., Loo, Peter Van, Morris, Quaid D., Boutros, Paul C.
Publicat a Nat Methods (2021)

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality

per Dimitriou, Marios, Woll, Petter S., Mortera-Blanco, Teresa, Karimi, Mohsen, Wedge, David C., Doolittle, Helen, Douagi, Iyadh, Papaemmanuil, Elli, Jacobsen, Sten Eirik W., Hellström-Lindberg, Eva
Publicat a Oncotarget (2016)

Neutral tumor evolution?

per Tarabichi, Maxime, Martincorena, Iñigo, Gerstung, Moritz, Leroi, Armand M., Markowetz, Florian, Spellman, Paul T., Morris, Quaid D., Lingjærde, Ole Christian, Wedge, David C., Van Loo, Peter
Publicat a Nat Genet (2018)

Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression

per Mamlouk, Soulafa, Simon, Tincy, Tomás, Laura, Wedge, David C., Arnold, Alexander, Menne, Andrea, Horst, David, Capper, David, Morkel, Markus, Posada, David, Sers, Christine, Bläker, Hendrik
Publicat a BMC Biol (2020)

Fast randomization of large genomic datasets while preserving alteration counts

per Gobbi, Andrea, Iorio, Francesco, Dawson, Kevin J., Wedge, David C., Tamborero, David, Alexandrov, Ludmil B., Lopez-Bigas, Nuria, Garnett, Mathew J., Jurman, Giuseppe, Saez-Rodriguez, Julio
Publicat 2014

ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data

per Raine, Keiran M., Van Loo, Peter, Wedge, David C., Jones, David, Menzies, Andrew, Butler, Adam P., Teague, Jon W., Tarpey, Patrick, Nik-Zainal, Serena, Campbell, Peter J.
Publicat a Curr Protoc Bioinformatics (2016)

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype

per Nangalia, Jyoti, Nice, Francesca L., Wedge, David C., Godfrey, Anna L, Grinfeld, Jacob, Thakker, Clare, Massie, Charlie E., Baxter, Joanna, Sewell, David, Silber, Yvonne, Campbell, Peter J., Green, Anthony R.
Publicat a Haematologica (2015)

Genomic copy number predicts esophageal cancer years before transformation

per Killcoyne, Sarah, Gregson, Eleanor, Wedge, David C., Woodcock, Dan J., Eldridge, Matthew, de la Rue, Rachel, Miremadi, Ahmad, Abbas, Sujath, Blasko, Adrienn, Kosmidou, Cassandra, Januszewicz, Wladyslaw, Jenkins, Aikaterini Varanou, Gerstung, Moritz, Fitzgerald, Rebecca C.
Publicat a Nat Med (2020)