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Deciphering Signatures of Mutational Processes Operative in Human Cancer

The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell. Remarkably, these mutational processes are poorly characterized. Global sequencing i...

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Autors principals: Alexandrov, Ludmil B., Nik-Zainal, Serena, Wedge, David C., Campbell, Peter J., Stratton, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588146/
https://ncbi.nlm.nih.gov/pubmed/23318258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.12.008
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