Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Pancreatic adenocarcinoma has the worst mortality of any solid cancer. In this study, to evaluate the clinical implications of genomic alterations in this tumour type, we perform whole-exome analyses of 24 tumours, targeted genomic analyses of 77 tumours, and use non-invasive approaches to examine t...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Sausen, Mark, Phallen, Jillian, Adleff, Vilmos, Jones, Siân, Leary, Rebecca J., Barrett, Michael T., Anagnostou, Valsamo, Parpart-Li, Sonya, Murphy, Derek, Li, Qing Kay, Hruban, Carolyn A., Scharpf, Rob, White, James R., O'Dwyer, Peter J., Allen, Peter J., Eshleman, James R., Thompson, Craig B., Klimstra, David S., Linehan, David C., Maitra, Anirban, Hruban, Ralph H., Diaz, Luis A., Von Hoff, Daniel D., Johansen, Julia S., Drebin, Jeffrey A., Velculescu, Victor E.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634573/
https://ncbi.nlm.nih.gov/pubmed/26154128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8686
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