A machine learning approach for somatic mutation discovery

Variability in the accuracy of somatic mutation detection may affect the discovery of alterations and the therapeutic management of cancer patients. To address this issue, we developed a somatic mutation discovery approach based on machine learning that outperformed existing methods in identifying e...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Wood, Derrick E., White, James R., Georgiadis, Andrew, Van Emburgh, Beth, Parpart-Li, Sonya, Mitchell, Jason, Anagnostou, Valsamo, Niknafs, Noushin, Karchin, Rachel, Papp, Eniko, McCord, Christine, LoVerso, Peter, Riley, David, Diaz, Luis A., Jones, Siân, Sausen, Mark, Velculescu, Victor E., Angiuoli, Samuel V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481619/
https://ncbi.nlm.nih.gov/pubmed/30185652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aar7939
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